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Inflammatory Response after the Implantation of Bioresorbable Vascular Scaffolds vs. 2nd Generation Druh-eluting Stents
Novotný, Vojtěch ; Šťásek, Josef (advisor) ; Kala, Petr (referee) ; Kočka, Viktor (referee)
The concept of bioresorbable scaffolds (BVS) originated in the 90s of the 20th century, however, the first commercially available coronary BVS was Absorb BVS in 2011. The dissertation deals with aspects of working with this type of BVS and its use in real practice. We focused on examining the inflammatory response after implantation of Absorb BVS in comparison with the proven 2nd generation metallic drug eluting stent (DES). The introduction systematically discusses the topic of BVS from history, through the composition of BVS and implantation techniques to available literature data. The second topic discussed is the inflammatory response after coronary stent implantation, we provide an overview of available data from studies and the introduction of inflammatory markers, which were analyzed in the main study. The presented work includes three main studies. A Pilot study in which we evaluated the systemic inflammatory response to coronary artery trauma caused by percutaneous coronary intervention previously described in the literature. We verified that the selected laboratory-determined markers of systemic inflammation (hs-CRP, IL-6 and serum amyloid A) increase significantly 24/48 hours after PCI compared to basal. This pilot study was directly followed by the Randomized study, in which we randomly...
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The Origin and Development of Interventional Cardiology and the Role of Nurses in the Field
Hašková, Martina ; Hocková, Jana (advisor) ; Kulhavá, Miluše (referee)
The diploma thesis addresses the historical development of interventional cardiology, an important field of medicine, which improves the prognosis and quality of life of patients with cardiovascular diseases. The goal of the work is to describe the evolution of interventional cardiology from humble beginnings to present day and to point out important events and historical moments which led to breakthroughs in cardiology and to demonstrate the role of nurses, important members of catheterization laboratory teams. Several sources were analyzed in this theoretical work, mainly articles from scientific journals and textbooks, the gathered information was complemented by interviews with medical professionals witnessing the origins of interventional cardiology in Czech Republic. The result of the thesis is an overview of the development of interventional cardiology since the demanding first steps, through the performance of the first coronary angioplasty to the wide array of diagnostic and therapeutic procedures replacing some of the cardiac surgery procedures of the present day. keywords: interventional cardiology, heart catheterization, percutaneous coronary intervention, intensive care
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